For her role, Hayes received a nomination for the Primetime Emmy Award for Outstanding Actress in a Short Form Comedy or Drama Series in 2016.

She has played roles in a number of network sitcoms, including Alison on The Winner (2007), Melanie Clayton on Worst Week (2008–2009), Sheila on Guys with Kids (2012–2013), and Donna Gable on Kevin Can Wait (2016–2017).

[3] Also, in that same year, she played the role of Pam Dawber in the TV movie Behind the Camera: The Unauthorized Story of Mork & Mindy alongside costar Chris Diamantopoulos.

[4] Hayes played the role of Dr. Lola Spratt in the satirical comedy series Childrens Hospital on Adult Swim.

In January 2020, Hayes played the role of Lola Spratt in the series Medical Police, with co-star Rob Huebel, for distribution on Netflix.