[3] He began medical training in 1882 and was heavily influenced by his brother Arthur Neve who had already dedicated himself to missionary work in Kashmir.

Following in his brother's footsteps, he lived among the poorest districts in Edinburgh and attended to the sick there, allowing him to gain unique experience.

He continued the work of his predecessors Dr. William Jackson Elmsie, Dr. Theodore Maxwell, and Dr. Edmond Downes.

[6] The Neve brothers converted the dispensary at Soloman Hill from a line of mud huts into a modernized hospital.

The staff that joined included Dr. Cecil Vosper, Dr. M. R. Roche and three English nurses, Nora Neve, Lucy McCormick and H. Smith.

[3] This hospital was funded by the Maharaja and was built on a piece of land granted by the British Commander-in-Chief of the Kashmir Army.

[9] Recognizing that tuberculosis and leprosy are preventable through proper sanitary measures, he made recommendations in 1912 to the Home minister of the State Council.

[9] In an article published in the Indian Medical Gazette, Neve shared his success with the surgical treatment of glandular tuberculosis.

[17] The introduction of a supply of pure water and better sanitary measures helped save hundreds of lives in Srinagar.

The Mohammedan priests proclaimed that to avert the pestilence, the tank in the courtyard of the sacred edifice should be filled with water brought by the worshippers.

[19] The vaccine greatly benefited the infant population since almost all children contracted smallpox and fifty percent died in infancy.

[21] In 1923, Ernest Neve reported the results of his success with the surgical treatment of Kangri-burn cancer in the British Medical Journal.

[6][22] He also published many articles and papers about the causes of and treatments for Kangri-burn cancer, including detailed descriptions of the operation.

[33] During World War 1 from 1914 to 1918, Ernest Neve served in the army as the captain of the Indian Defense Force Medical Corps.

[1] He received the Gunning-Lister Prize in Surgery of Edinburgh University in 1888,[34] and was elected a Fellow of the Royal College of Surgeons of England, as a member of twenty years' standing, in 1931.

[36] Ernest Neve retired from medical work in 1934 but continued to live at Sonawar Bagh, Srinagar, where he died on 6 February 1946, aged 85.

He also made significant contributions to the medical community and published new findings on a wide variety of surgical topics.