He played various blues musicians and bands, including with Pinetop Perkins, Robert Nighthawk, Ike Turner, George "Harmonica" Smith, and Canned Heat.

Lane and his siblings, three sisters and two brothers, lived with his mother Ethel Thomas in Clarksdale.

One day, Lane and Turner heard blues pianist Pinetop Perkins playing boogie-woogie at his father's house.

on Blues & Rhythm Records, which was a short lived label founded and run by Saul Bihari.

[5] Lane relocated to California in 1956 where he performed with Jimmy Nolen and George "Harmonica" Smith.