Ernest Othmer Thompson (March 24, 1892 – June 28, 1966) was an American politician, lawyer, and businessman who served as the 12th mayor of Amarillo from 1929 to 1932 as a member of the Democratic Party.

The following year, President Franklin D. Roosevelt sent Thompson as an American delegate to the World Petroleum Conference in France.

[4] Thompson was an unsuccessful candidate for governor of Texas in 1938; he was defeated by radio host and businessman W. Lee O'Daniel in the Democratic primary.

Due to the Allies's need for a steady supply of fuel, Thompson was sent back to Texas to fulfill his duties on the Railroad Commission.

[3] On October 1, 1952, May Thompson suffered a cerebral hemorrhage at the couple's summer house in Estes Park, Colorado, causing her to lapse into a coma.

She was flown back to Austin, Texas, though never regained consciousness and died at Seton Infirmary on October 8, the day after her 72nd birthday.