[5][6] After teaching at Kototabi Mixed school for two years she then returned to STC to obtain a Diploma in Home Economics.

With a desire to continuously improve herself whilst teaching, she attended the University of Ghana, Legon and completed a Bachelor of Arts degree in Sociology and Psychology.

[5][6] In 1995, Her husband, John Evans Atta Mills was selected as vice presidential running mate to Jerry John Rawlings replacing Kow Nkensen Arkaah when he ran for a second term as President of Ghana in 1996, becoming second lady when he was sworn into office on 7 January 1996.

[12][13] In December 2009, Mills launched the Free School Uniform initiative in collaboration with the Ministry of Education and Ministry of Local Government and Rural Development as an initiative earmarked to distribute 1.6 million school uniforms to 77 deprived districts in Ghana.

"[19][20][21] Mills set up a Non-governmental organisation called the Foundation for Child Education Ghana (FCEG) whilst she was First Lady.

[4][3] The Foundation which is a community-based organization set up to promote education in the deprived, rural and poor communities in Ghana.

[26] She spoke at the conference and made calls on the need for countries to emphasize their attention on issues relating to youth development.

In June 2013, Mills launched the Senior High School (SHS) Students’ Bible Project, an initiative in partnership with the Scripture Union (SU) Ghana, and Tyndale Publishers where a total of 500,000 Bibles, printed by the Tyndale House Publishers in the United States (USA), at a cost of GH¢10,000, was to be shared among SHS students by the Scripture Union (SU) Ghana.

[5] Mills was awarded with an honorary doctorate of humane letters degree by Goodwin College, East Hartford, in Connecticut, USA, at the school's commencement ceremony in July 2011 for devoting her life to improving the access and quality of education of underprivileged children and enhancing girl child education in Ghana.