Enno studied business administration from 1896 to 1904 at the Riga Polytechnic Institute.
After studying Enno was briefly a general counsel at the credit union in Valga and in a trading company in Pärnu.
In 1909, Enno married the artist Elfriede Olga Saul (died 1974 in exile in the UK).
The work of Ernst Enno is influenced by Buddhism and Western mysticism.
The childhood spent in the countryside, the stories of his devout mother Ann Enno and his blind grandmother had a formative influence on his literary work.