Erskine Seminary is in the conservative Presbyterian tradition, and primarily prepares candidates for ordained Christian ministry.

The mission of Erskine Theological Seminary is to prepare "men and women to fulfill the Great Commission of Jesus Christ through theological higher education that is ecclesial, missional, and confessional.

"[2] On April 22, 2011, five members of the Erskine College and Seminary faculties issued a Good Friday Statement addressing toleration of neo-orthodoxy among the Seminary faculty and supporting their understanding of the Bible as "inerrant in the original autographs" as the official position of the Associate Reformed Presbyterian Church.

Michael A. Milton, the former chancellor of Reformed Seminary, president of Knox Theological Seminary, Chaplain (Colonel) USA Ret., and a longtime pastor in the Presbyterian Church in America, became Provost in December 2019.

[4] Erskine Theological Seminary offers residential study at its campuses in Due West, Columbia, and Greenville, South Carolina.