In 1920, the trustees determined to move the seminary to St. Louis, Missouri, also to be nearer to potential students in the Plains states.

This institution was later augmented by the resources of Newburgh Seminary, founded in New York City in 1805 by John Mitchell Mason.

It was indeed a western seminary in 1825, furnishing a ministry for the rapidly opening frontier territories along the Ohio River.

The seminary has scholars in all major fields of theological inquiry and offers language training in Greek and Hebrew.

Its 300,000 volumes, several online databases, and more than 800 periodical subscriptions make it one of the larger stand-alone theological libraries in the United States.

[7] Many of the books and periodicals in the collection were made possible by a $15 million gift from wealthy banker and businessman Thomas Clinton.

The museum contains a collection of ancient Near Eastern and Palestinian pottery and artifacts brought together by travelers and archeologists over the past 60 years.

In July 2005 excavators discovered the Zayit Stone, which contained an inscription dating to the 10th century BCE (King Solomon's reign).

The two-line inscription, on a 33-pound limestone boulder embedded in the stone wall of a building, is the earliest securely-dated example of the complete Hebrew alphabet (an "abecedary").