In March 1951, the unit was redesignated Fighter Squadron 2/5 Ile-de-France and it moved to BA 115 Orange-Caritat and transitioned to the de Havilland Vampire.

At this point the unit's history closely follows that of the other squadron based in Orange, Escadron de Chasse 1/5 Vendée.

In September 1992, EC 2/5 Ile-de-France earned the distinction of being the first unit of the French Air Force to be deployed in Saudi Arabia to enforce the no-fly zone imposed in Iraq.

Since 1997, EC 2/5 Ile-de-France is responsible for training and operational transformation of all Mirage 2000 pilots, though its main mission remains air defense.

The aircraft arrived in Poland on 2 June 2014 to relieve four French Dassault Rafales as part of NATO's response to Russian aggression in Ukraine.