Many story premises, both originals and adaptations, involved a protagonist in dire life-or-death straits, and the series featured more science fiction and supernatural tales than Suspense.
Some of the memorable adaptations include Daphne du Maurier's "The Birds", Carl Stephenson's "Leiningen Versus the Ants", Algernon Blackwood's "Confession", Ray Bradbury's oft-reprinted "Mars Is Heaven", George R. Stewart's Earth Abides (the program's only two-parter), Richard Connell's "The Most Dangerous Game" and F. Scott Fitzgerald's "The Diamond as Big as the Ritz".
John Collier's "Evening Primrose", about people who live inside a department store, was later adapted to TV as a Stephen Sondheim musical starring Anthony Perkins.
Other actors on the series included Elvia Allman, Eleanor Audley, Parley Baer, Michael Ann Barrett, Tony Barrett, Harry Bartell, Ted Bliss, Lillian Buyeff, Ken Christy, William Conrad, Ted de Corsia, John Dehner, Don Diamond, Paul Dubov, Sam Edwards, Virginia Gregg, Lou Merrill, Howard McNear, Jess Kirkpatrick, Dee J. Thompson, Shep Menken, Frank Gerstle, George Neise, Jeanette Nolan, Dan O'Herlihy, Barney Phillips, Forrest Lewis, Robert Griffin, Alan Reed, Bill Johnstone, Sandra Gould, Junius Matthews, Carleton G. Young, Marvin Miller, Frank Lovejoy, Berry Kroeger, Vic Perrin, Elliott Lewis, Eleanore Tanin, Herb Vigran, Jack Webb, Peggy Webber, and Will Wright.
Music was supplied by Del Castillo, organist Ivan Ditmars, Cy Feuer, Wilbur Hatch and Leith Stevens.