Formula plot devices were followed for all but a handful of episodes: the protagonist was usually a normal person suddenly dropped into a threatening or bizarre situation; solutions were "withheld until the last possible second"; and evildoers were usually punished in the end.

Notable exceptions include adaptations of Curt Siodmak's Donovan's Brain and H. P. Lovecraft's "The Dunwich Horror", but by the late 1950s, such material was regularly featured.

Herbert Marshall portrayed the mysterious lodger, and co-starring with him were Edmund Gwenn and character actress Lurene Tuttle as the rooming-house keepers who start to suspect that their new boarder might be the notorious Jack-the-Ripper.

Character actor Joseph Kearns also had a small part in the drama, and Wilbur Hatch, head musician for CBS Radio at the time, composed and conducted the music specially for the program.

Adapting the script to radio was not a great technical challenge for Hitchcock, and he cleverly decided to hold back the ending of the story from the listening audience in order to keep them in suspense themselves.

Actually a few wrote threats claiming that it was "indecent" and "immoral" to present such a production without giving the solution In the earliest years, the program was hosted by "The Man in Black" (played by Joseph Kearns or Ted Osborne) with many episodes written or adapted by the prominent mystery author John Dickson Carr.

One of the series' earliest successes and its single most popular episode is Lucille Fletcher's "Sorry, Wrong Number", about a bedridden woman (Agnes Moorehead) who panics after overhearing a murder plot on a crossed telephone connection but is unable to persuade anyone to investigate.

[opinion] The writing was taut,[opinion] and the casting, which had always been a strong point of the series (featuring such film stars as Orson Welles, Joseph Cotten, Henry Fonda, Humphrey Bogart, Judy Garland, Ronald Colman, Marlene Dietrich, Eve McVeagh, Lena Horne, and Cary Grant), took an unexpected turn when Lewis expanded the repertory to include many of radio's famous drama and comedy stars – often playing against type – such as Jack Benny.

On the May 10, 1951 Suspense, Lewis reversed the roles with "Death on My Hands": A bandleader (Harris) is horrified when an autograph-seeking fan accidentally shoots herself and dies in his hotel room, and a vocalist (Faye) tries to help him as the townfolk call for vigilante justice against him.

With the rise of television and the departures of Lewis and Autolite, subsequent producers (Antony Ellis, William N. Robson and others) struggled to maintain the series due to shrinking budgets, the availability of fewer name actors, and listenership decline.

A time travel tale like Robert Arthur's "The Man Who Went Back to Save Lincoln" or a thriller about a death ray-wielding mad scientist would alternate with more run-of-the-mill crime dramas.

[8] In 2012, John C. Alsedek and Dana Perry-Hayes of Blue Hours Productions revived Suspense for Sirius XM Radio, recording all-new scripts including originals and adaptations of works by the likes of H.P.