Escher Wyss is a quarter in the district 5 of Zürich, centered on the Escher-Wyss-Platz square.
Escher Wyss was formerly a part of Aussersihl municipality, which was incorporated into Zürich in 1893.
It takes its name from the company Escher Wyss & Cie. that was formerly based in the area.
The company's former Schiffbau, or shipbuilding hall, is now a theatre venue operated by the Schauspielhaus Zürich.
Zürich trolleybus routes 33 and 72 pass through the quarter on the Hardbrücke elevated roadway, serving stops above Escher-Wyss-Platz.