Escuintla (Spanish pronunciation: [esˈkwintla]) is one of the 22 departments of Guatemala.

The capital of the department is the city of Escuintla.

Escuintla covers an area of 4,384 km2 and is situated in the coastal lowland region, directly south of Guatemala City, and bordered by the Pacific Ocean.

Escuintla produces about 43 percent of gross domestic product of Guatemala.