Esen Buqa II (Chagatai: اسن بوقا ثانی; died 1462) was Khan of Moghulistan from 1429 until his death.
The first few years of his reign went by smoothly; all of the Moghuls were loyal to him, while the town of Kashgar, which had been captured by the Timurids after Uwais Khan had died, was retaken in 1435.
As result he gave his daughter Daulat Nigar Khanim in marriage to Muhammad Haidar Mirza, son of Dughlat Amir of Kashgar Sayyid Ali.
Esen Buqa caught him a few miles from the town and in the ensuing battle proved victorious, forcing his brother to flee back to Abu Sa'id.
A short time later Esen Buqa again had to deal with Yunus Khan, who once again gained the support of the amirs when he entered Moghulistan, but was unable to make any real headway against his brother.