Esofea, Wisconsin is an unincorporated community in the town of Jefferson in Vernon County, Wisconsin, United States located along County Road B.

[1][2] In the early 1900s Esofea was a stopping point for travelers on horse going between Viroqua and La Crosse.

The community had a creamery, general store, school house, and post office.

A tornado landed near Esofea on August 18, 2005 at the time of The Wisconsin Tornado Outbreak of August 2005.

This article about a location in Vernon County, Wisconsin is a stub.