Mami Sakura used to be a normal junior high school student, but she happened to acquire supernatural powers.

Her telekinesis can be precise to a cellular level, which enables her to transport cancerous cells out of one of her father's art critics.

The animated adaptation of the series aired in Japan from April 7, 1987, to October 26, 1989, with 119 episodes and a TV special being broadcast.

The "Dancing Dolls in the Starlit Sky" short film, which had originally premiered in Japanese theaters on March 12, 1988, as a pre-movie bonus before Doraemon: The Record of Nobita's Parallel Visit to the West, was also released on a 2003 VHS cassette tape with the "Pro Golfer Saru" short film.

In order to make up for their error, the publisher of the DVDs included a mail-in form in which those who bought both box sets could send in proof of purchases for them and receive a "ESPer Mami Special DVD" that contained the next episode previews for all 119 episodes, along with the unaired pilot film for the series, creditless opening and ending theme songs, promotional videos used to promote the series prior to it first premiering, and the animated interstitials for the TV special that were edited out of the main DVDs.

This new anniversary set was released with the same material as the two previous 10-disc box sets and the Special DVD, except that the previews for episodes 1-60 were included at the end of each episode, and the space that was used for the previews on the Special 21st disc was replaced with the "Dancing Dolls in the Starlit Sky" animated movie that had not previously been released on DVD.

Japan had picked up the rights to stream a new digitally remastered 1080p HD version of the ESPer Mami series on their "GYAO!"