Estill is a town in Hampton County, South Carolina, United States.

The John Lawton House and Lawtonville Baptist Church are listed on the National Register of Historic Places.

In the early morning hours of April 13, 2020, a large, violent EF4 Tornado struck areas just south of Estill.

The nearby community of Nixville, South Carolina suffered a direct hit from the tornado, and sustained the brunt of the twister's impacts.

As of the 2020 United States census, there were 1,821 people, 889 households, and 620 families residing in the town.