Founded in 2016, it was the reserve team of FC Jumilla, and last played in Tercera División – Group 13, holding home games at Polideportivo Municipal Ángel Sornichero in Alcantarilla, with a capacity of 400 spectators.

Estudiantes' origins trace back to 1964 with the foundation of Nueva Vanguardia CF (a club mainly dedicated to the youth categories), which merged with Espinardo Atlético (founded in 2013 and playing that season under the name of Sporting de Murcia CF) in August 2015, to become CF Espinardo Atlético Nueva Vanguardia.

In July 2016, the club became FC Jumilla's reserve team, being renamed Nueva Vanguardia Estudiantes de Murcia Club de Fútbol.

[2] In the following year, the club changed name to Estudiantes CF and ended their partnership with Jumilla, but as the agreement was reinstated in June 2018, the club changed back to its previous name.

[3] In August 2019, after Jumilla were dissolved, Estudiantes de Murcia also folded.