It features the score, composed by Los Angeles musician Jon Brion, as well as songs from artists Electric Light Orchestra (ELO), the Polyphonic Spree, the Willowz, and Don Nelson.

Three filmi songs from old Hindi movies can be heard playing in the background (when Clementine invites Joel to her apartment for a drink).

Among these are Brian Eno's Music for Airports (1978), the instrumental live version of the same by Bang on a Can (1998), Björk's Homogenic (1997) and Tom Waits's Rain Dogs (1985).

Roc Nation artist Jay Electronica sampled five Jon Brion compositions from the soundtrack for his debut mixtape Act I: Eternal Sunshine (The Pledge).

Don Nelson's song "Some Kinda Shuffle" was briefly featured in Luc Besson's 2017 space opera film Valerian and the City of a Thousand Planets