Adapted from the 1993 novel of the same name by Jullie Yap-Daza, it features an ensemble cast[4] including Kris Aquino, Claudine Barretto, Iza Calzado, Cheena Crab and Kim Chiu.

The film tackles the lives of five successful and glamorous women whose friendship is based on their common weaknesses—they are all trapped in the prison of their hearts.

In a lounge bar, Chloe, the most rebellious mistress is embarrassed her credit card being cancelled by her lover Gabriel.

The girls start to form a stronger friendship and bond at a mall and a beauty salon using Charley's credit card.

In Georgia's absence, Ina stays with Charley and accompanies her to an auction but she is caught by Wang Gie's wife and suspended from going out.

Ina attends Senator Adelle Ayson's birthday party to get a glimpse of Frank with Chloe's assistance.

Prior to the accident, Ambet is diagnosed with cancer and is terminally ill. After a talk with Gabriel's wife, Chloe faces her friends again but nobody is interested to listen to her realization that their lovers will never choose them.

Charlie decides to break a rule in order for Stella and Ambet escape using Frank's influence and Wang Gie's plane.

According to Rappler, ''Etiquette for Mistresses' is a breath of fresh air amidst the countless films about infidelity that offer nothing more than outrageous confrontations as cheap entertainment."