In the summer of 2013, Italian club Chievo announced that they had a pre-contract agreement in place with Berisha, but he instead joined their Serie A rivals Lazio on a four-year deal, which caused controversy and led to the player being faced with a six-month suspension, although the case was eventually dropped against him.

Berisha played an instrumental role in Albania qualifying for its first major international tournament, UEFA Euro 2016, becoming a fan favourite in the process.

[4] He impressed in the youth side and was eventually promoted to the first team ahead of the 2010 Allsvenskan, where he was initially regarded as backup to veteran goalkeeper and Kalmar legend, Petter Wastå.

His first taste of first team football came in the first game of the season on 13 March 2010 against IFK Göteborg, where he was an unused substitute in the 3–0 home loss.

Towards the end of the season he cemented his spot as the first choice goalkeeper with some impressive displays, losing just once during the 14 league games he played in, and keeping seven clean sheets in the process.

Berisha played his last game for Kalmar against Halmstads BK on 1 September 2013 and scored from a penalty to give his team the 1–0 victory.

[11] His impressive performance convinced the coach Vladimir Petković to give him another starting place in the next Europa League fixture against Legia Warszawa three weeks later, and Berisha managed to keep the clean-sheet by making some notable saves to help his team to take an away 2–0 win.

[16] He managed to play also in the next match in Coppa Italia against Napoli valid for the quarter-finals where Lazio lost 1–0 to be eliminated from the competition.

[22] Berisha played in the last match of the season on 18 May 2014, keeping the clean sheet in the victory 1–0 against Bologna with a late penalty score by Lucas Biglia in the 4th minute of stoppage time.

Berisha kept the clean-sheet in his debut of the 2014–15 new season at the match valid for 2014–15 Coppa Italia against Bassano Virtus, finished in the 7–0 victory.

[31] He kept a clean sheet against the eventual third place team Napoli on 26 February 2017 with several decisive saves helping Atalanta to take an away win at Stadio San Paolo.

[40] Berisha received his first senior international call up by the Albania national team coach Gianni De Biasi for friendlies against Qatar and Iran in May 2012.

[41] He made his debut for Albania against Iran at the İnönü Stadium, Istanbul, Turkey, playing the full 90 minutes and keeping a clean sheet in a 1–0 win.

On 22 March 2013, in the match against Norway in Oslo, Berisha produced a flawless performance as he made several decisive saves, leading Albania into 1–0 win, the first ever versus them.

[51] After the qualifiers, fellow goalkeeper Ujkani switched to play for Kosovo, making Berisha the only first choice of Albania, with Shehi as second-hand.

[53] On 14 October 2014, in the matchday 4 away against Serbia, Berisha played as a starter until 42nd minute where the match was postponed due to Serbian fans launching flares onto the pitch.

[56] On 4 September 2015, Berisha made several good saves which ensured Albania a point in the away match against Denmark, which brought the team closer to the "European dream".

[64] In the third and last group match against Romania, Berisha took his first clean sheet as Albania won 1–0 for first victory in a major football tournament.

[66] Albania finished the group in the third position with three points and with a goal difference –2, and was ranked last in the third-placed teams, which eventually eliminated them.

In the next game against Spain on 10 October, Berisha managed to keep a first-half clean sheet and then ten minutes after the start of the second-half he made a mistake when clearing the ball giving David Silva opportunity to take the ball and to give an immediate pass to Diego Costa who scored at an empty net.

[70] On 12 November 2016, during the home game against Israel, Berisha was involved in a physical clash against Israeli striker Eran Zahavi, ultimately knocking him down with a headbutt and being immediately executed and banned from the tournament for an undecided period of time.

[76] On 11 September 2013, Lazio's president Claudio Lotito declared that Berisha was bought and signed in the regular way according to the Transfer Window rules.

[77] On 14 September 2013, the sport director of Chievo Giovanni Sartori accused Berisha of changing his mind for more money at Lazio.