[2] He left Modena in 2003, after having led his club to safety, achieving an impressive 13th-place finish in the Serie A table, and signed for Brescia, where he had the opportunity to coach Roberto Baggio in his last playing season of his career.
De Biasi, initially confirmed as head coach also for the 2006–07 Serie A campaign, was however sacked three days before the first matchday and replaced by Alberto Zaccheroni.
On 26 February 2007 Torino FC chairman Cairo decided to sack Zaccheroni too and recall De Biasi at the helm of the granata, leading them to avoid relegation.
Despite the lack of top-quality players and as the risk of bankruptcy loomed, he led the team to some unexpected victories, displaying linearity and tactical discipline that gained him the love of the Spanish fans and esteem of the critics: in one of its editions, the popular sports daily “As” declared him the best coach in the championship On 16 April 2008, he was announced by Torino to replace Walter Novellino for the five final matchdays, with the aim to save the club from relegation once again.
[5] On 22 December 2009, Udinese dismissed manager Pasquale Marino and appointed De Biasi to take charge of the struggling team from North-Eastern Italy.
However, results did not particularly improve under his tenure as head coach, and De Biasi himself was removed from his post on 21 February 2010 with Marino being named back at the helm of the club.
[6] On 14 December 2011, following Josip Kuže's dismissal, the Albanian Football Association announced to have agreed a two-year deal with De Biasi as new head coach of the national team for the 2014 FIFA World Cup qualifiers.
[19] In the next qualifying match against Denmark at the newly renovated Elbasan Arena, Albania was on lead until 81st minute when Lasse Vibe levelled the score to 1–1.
[23] On 13 June 2015, Albania beat one-time World Champions France at Elbasan Arena for the first time in history thanks to a free-kick from Ergys Kaçe.
[26][27] For this achievement De Biasi, as well as the entire team were bestowed the Honor of Nation Order by Albania's President Bujar Nishani.
[28] At the end of 2015, De Biasi was included for the first time in the top ten IFFHS National Coaches of the World, ranking sixth.
[33] After losing narrowly to Switzerland in their opening game,[34] Albania held hosts and favourites France scoreless until the 89th minute before conceding two late goals.