They flourished over a large part of the northern half of Italy starting from the Iron Age, and in some cases reached a substantial level of wealth and power.
They were eventually assimilated first by Italics in the south, then by Celts in the north and finally in Etruria itself by the growing Roman Republic.
The estimates for the populations of the largest cities (Veii, Volsinii, Caere, Vulci, Tarquinia, Populonia) range between 25,000 and 40,000 each in the 6th century BC.
[6] By the time the dodecapolis had sprung into the light of history, the Etruscan cities to the north had been assimilated by invasions of the Celts, and those of the south by infiltration of the Italics.
[citation needed] Etruscan cities were autonomous states, but they were linked in the dodecapolis and had a federal sanctuary at the Fanum Voltumnae near Volsinii.