[2][3] Doane was commissioned by the American Board of Commissioners for Foreign Missions in 1881, in Boston, to be Congregationalist teacher in Turkey.
[4][5] She remained there from 1881 to 1825, serving first in Marash (Maraş), and later at a school in the Gedik Pasha (Gedikpaşa) quarter in Constantinople.
[12][13][14] In 1910 she sailed from Liverpool to Boston on the Lusitania,[15] and in 1910 and 1911 Marden toured in the United States with other American missionary women,[16] including Jennie V. Hughes, Helen Barrett Montgomery, and Mary Riggs Noble, to speak at jubilee celebrations in various cities.
[17][18] She left Constantinople to spend a health leave in Switzerland in the summer of 1917,[19] and was giving lectures in the United States the following spring.
[21] She wrote to the editors of the Los Angeles Times to protest unsubstantiated information they published about "Turkish harems".