[1] Eudistoma is the most species-rich genus in the family Polycitoridae, with 124 valid species as of 2014.

[2] In 1909 Caullery described Eudistoma as a subgenus of Distoma due to the rows of stigmata in the pharynx.

Eudistoma was finally considered a valid genus in 1945 due to "the three rows of pharyngeal slits, long esophagus, flat stomach in the posterior region of the abdomen, very conspicuous longitudinal muscles extending from the pharynx to the end of the abdomen and larvae that are incubated in the atrial cavity."

Identification of species within the genus has been difficult at times due to the wide variety in shape and colour.

[2] Biologically active alkaloids have been isolated from a number of species of Eudistoma, some of which have been studied for their cytotoxic properties.