His father, Nicolae Mihăescu, was the assistant of a famous Romanian literature historian and critic, Tudor Vianu, at the university in the capital city.
Mihăescu was responsible for the innovative graphic design concept of the magazine but he lost his job in 1963 because of a critic who accused him in the Communist Party’s most important journal, Scanteia, of being an "admirer of the decadent capitalist art".
Eugene Mihaesco joined the team led by John B. Oakes and Harrison Salisbury who wrote in his book entitled The Indignant Years – Art & Articles from the Op-Ed Page of The New York Times (Crown Publishers/Arno Press, 1971): "Art is not employed on Op-Ed to illustrate, to give the reader a picture of the scene the writer is trying to describe.
The image is employed not as a visual aid, a space device for breaking blocks of type, a means to crystallising abstract concepts.
His drawings were reproduced in the Graphis magazine, one of the most important publications for graphics and design, which dedicated two of its issues to Eugene Mihaesco's work.
As Philip Beard said: "Graphis magazine was an immensely influential Swiss publication founded by Walter Herdeg that showcased the best in graphic design and illustration from its first issue in 1944."
Between 2001 and 2003 Eugene Mihaesco was appointed Romania's Permanent Delegate to UNESCO in Paris and was a member of the Executive Comity of the international organisation.