Eugene is an unincorporated community in extreme southwestern Cole County, Missouri, United States.

[3] It is located 10 miles (16 km) east of Eldon on Route 17, approximately 3 miles (5 km) south of U.S. Route 54.

[4] A post office called Eugene has been in operation since 1904.

[5] Cole County R-V School District is located in Eugene and has a K-12 enrollment of approximately 620 students.

This Cole County, Missouri state location article is a stub.