It is native to North America, where it is generally considered a common weed, it can be found in disturbed soils such as garden beds, along railroad tracks, and in the cracks of sidewalks.

[6] As originally described in 1753 by Carl Linnaeus, Euphorbia maculata is an herbacous plant with small, oblong opposite leaves.

The cyathia, bisexual reproductive structures unique to plants in the genus, are very small, with four white petal-like appendages that are sometimes pink.

It may occasionally be confused with Euphorbia serpens but this taxon has very short and rounded leaves and larger (but still inconspicuous) cyathia.

[11] Euphorbia maculata is commonly found along roadsides, in the cracks and crevasses of sidewalks, and throughout North America.

The growth of E. maculata in agricultural fields may impact crops yields such as vegetables, legumes, and cereals.

Due to toxicity, the growth of Euphorbia maculata in pastures can cause sickness, vomiting, and weakness in livestock.

Spotted Spurge grows best in open, sunny areas, so mulching with a layer wood chips or straw prevent may smother the plant.