His name in Greek means "good sailing" which is played upon in the text of the Orthodox Christian Vespers service in his honor.

The Passion of Saint Euplius states that he was a deacon and that he was arrested for owning and reading from a copy of the Bible during the Diocletianic Persecution.

The remains of the Saint rest in the Cathedral of the Assumption of Trevico; it is plausible that they were brought just before the Arab invasion of Sicily in the 10th century.

[1] On 5 February 1654, the Bishop of Trevico, Donato Pascasio, authorized the translation of a bone of the saint in favor of the catanese diocese.

In 1471, a wooden church was erected in honor of the saint to celebrate the peace between the Grand Prince of Muscovy Ivan III and the Novgorod Republic.