The building was designed by John J. Donovan of Oakland and built by James McLaughlin of San Francisco.

[5] The site occupied by the current science building is on the location of the original high school main building, built by W. H. Weeks in 1914-1915, which was demolished after analysis deemed it too damaged to save following damage from earthquakes, culminating in the early 1960s.

It was remarkably similar to a high school Weeks designed for Santa Cruz, which survives and is in use to this day.

The school auditorium (located in the main building) was closed because of concerns related to structural security.

Course offerings include the following programs: Eureka High School is a member of the Humboldt–Del Norte Big 4 League.