The most significant scientific communities supported by EGI in 2022 were Medical and Health Sciences, High Energy Physics, and Engineering and Technology.

Through the EGI Federation, researchers gain access to advanced computing and data analytics capabilities, including large-scale data analysis, while benefiting from the collaborative efforts of hundreds of service providers from both public and private sectors, consolidating resources from Europe and beyond.

EGI Check-in and Secrets Store are key security and identity services, while applications such as Notebooks and Replay enhance research productivity.

In 2002, the first large-scale experimental facility was successfully demonstrated by the DataGrid project[4] under the lead of CERN with tens of technical architects from the major High Energy Physics institutes in the world.

2004 marks the year of the first pilot infrastructure, seeing the participation of CERN and data centres in the United Kingdom, Spain, Germany, the Netherlands, France, Canada, Russia, Bulgaria, the Asia-Pacific region and Switzerland.

Over the years, the infrastructure has grown into a federation of 128 data centres and 25 cloud providers serving more than 95,000 users worldwide.

The success of the project was due to the adoption of a distributed computing model to solve big data problems.

Moreover, EGI-Inspire harmonised operational policies across its federation of affiliated data centres and cloud service providers worldwide, integrating e-infrastructures from 57 countries.

In 2015, EGI, EUDAT, GÉANT, LIBER and OpenAIRE published a position paper[12] on a 'European Open Science Cloud for Research'.

In October 2024, EUDAT, GÉANT, OpenAIRE, PRACE and EGI signed a Memorandum of Understanding establishing the European e-Infrastructures Assembly.

[21] This collaboration will bolster the position and promote the services of e-Infrastructures, empowering researchers across Europe to drive innovation and advance scientific discovery.