Later he left the PPP to form ASCRIA (African Society for Cultural Relations with Independent Africa), a Pan-Africanist grassroots political group that, after a brief flirtation with the People's National Congress (PNC) of Forbes Burnham, fused into the Working People's Alliance (WPA).
Around 1947 (at that time known as Sydney King), he became a member of a small group of politicians, led by Cheddi Jagan, who formed the People's Progressive Party (PPP).
After the PPP won in Guyana's first election under universal adult suffrage, Kwayana became Minister of Communication and Works.
[3] After the British government suspended the constitution and threw the PPP out of office, in October 1953, Kwayana and others were made political detainees for fear that they would cause civil unrest.
[3] He is the author of several books, including Next Witness, The Bauxite Strike and the Old Politics, Scars of Bondage, Guyana: No Guilty Race, Buxton in Print and Memory, Morning After, Genesis of a Nation: The Indo-Guyanese Contribution to Social Change (in Guyana) and Walter Rodney: His Last Days and Campaigns.