Her height (1.80 m or 5 ft 11 in) and elegant appearance made her a sought-after model for fashion shows and campaigns of various renowned brands.

She became one of the prominent figures of the 1990s modeling and was one of the so-called supermodels along with other famous names such as Naomi Campbell, Cindy Crawford, Claudia Schiffer and Christy Turlington.

She has starred in films such as Les Anges gardiens (1995) along Gérard Depardieu and Christian Clavier, My Best Friend's Wife (1998), Modigliani (2004) and A Prominent Patient (2017).

In 1994, advertising executive Trevor Beattie, working for TBWA/London, developed an ad for Sara Lee's "Hello Boys" Wonderbra campaign.

[9] The Canada-based lingerie fashion label wanted the ad campaign to motivate women to see the Wonderbra "as a cosmetic and as a beauty enhancer rather than a functional garment".

Herzigová has featured in a variety of international fashion magazines, gracing the covers of Vogue (France, Britain, Spain, Germany, Japan, Australia, Mexico, Poland, Turkey, Thailand), Harper's Bazaar (Britain, Spain, Ukraine, Italy, Australia) as well as Elle, Marie Claire, Numéro and Allure.

She has also walked for designers including Louis Vuitton, Benedetta Dubini, Giles Deacon, Emilio Pucci and Versace.