[1] A member of the Democratic Party, he represented the 26th Assembly district, which encompasses parts of Silicon Valley, including Cupertino, Sunnyvale, Santa Clara and portions of northern and western San Jose.

[9] Low chaired the California Assembly Business and Professions Committee from March 2016 until November 2021, when he was removed without explanation by Speaker Anthony Rendon.

[15] In 2023, Low also supported ACA 7, a narrower effort "that would allow state agencies to consider race if academic research shows evidence those race-based programs could work.

[18] In 2016, New York Magazine identified Low as a potential United States presidential candidate in 2024 along with nine other young Democrats who, like Obama, have unusual ambition.

[19] In the 2017–2018 session, The Sacramento Bee identified Low as California's most prolific lawmaker, where he had the most bills signed by any member of the state legislature by Governor Jerry Brown.

[22] In 2023 in SB 815, language added by Low in AB 2098, was removed from California Law due to concerns it was unconstitutional being tested in Court.

In December 2023, Low announced his intention to run for California's 16th congressional district, which was held by retiring incumbent Anna Eshoo.

[25] After the primary in March 2024, Low and Santa Clara County supervisor Joe Simitian repeatedly traded the second-place position multiple times during the vote count.

[31] In October 2024, good-government group Defend the Vote[32] filed an FEC complaint against Low,[33] alleging that he had spent nearly $600,000[34] from his state campaign account on ads that were distributed across the congressional district.

The Mercury News Editorial Board reaffirmed their endorsement of Liccardo,[37] criticizing Low for “putting political self-interest ahead of campaign integrity.” After redistricting added Campbell to Assemblymember Marc Berman's district, Low announced he would run in the new 26th district spanning Sunnyvale, Cupertino, and Santa Clara.