[3] In June 2013, Universal acquired the remake rights to the Japanese 2007 anime film Vexille and set Spiliotopoulos to write the screenplay.
[4] In July 2014, Spiliotopoulos was hired by 20th Century Fox to write the script for the 2014 novel Seven Wonders written by Ben Mezrich.
[8] Spiliotopoulos wrote the screenplay of action-adventure fantasy film The Huntsman: Winter's War, along with Craig Mazin, and rewritten by Frank Darabont.
[9] Spiliotopoulos and Stephen Chbosky wrote Disney's live action musical romantic fantasy film Beauty and the Beast, which was directed by Bill Condon, and starring Emma Watson and Dan Stevens.
Spiliotopoulos received a "story by" credit, with David Auburn, for the Charlie's Angels reboot film of 2019, which was written and directed by Elizabeth Banks.