Her mother, Felipa Perozo, was an illiterate peasant who was left pregnant by Ramón Rodríguez, a wealthy merchant of the area who was also an officer in the army of Pedro Santana.
[1] At the age of 12 Rodríguez became a part-time home health aid to Dominican Poet and journalist Rafael Alfredo or "Pepe Cándido" Deligne (1863-1902) [1], who had fallen ill to leprosy.
[5] As a young and medical physician of color, Rodríguez attempted to make a living in San Pedro de Macorís but founded it challenging to do so as an inexperienced female doctor.
As a result of the lack of profits, Rodríguez moved to the region of Ramom Santana[4] which was home to the many who were part of the guerrilla resistant’s and oppose actively the American invasion of United States occupation of the Dominican Republic (1916–1924).
In 1921, three years of providing free medical care in San Francisco and neighboring poor rural communities, Rodríguez left for Paris so she could continue her studies and practice medicine.
Once she returned from Frances and saw a high rate of venereal disease, she began to provide free health care to women in need this included visiting the prostitute neighborhood.
[2] Rodríguez taught at the Young Ladies Institute during the day, and in the evenings at the Laborers and Domestic Workers Night School (Escuela Nocturna para Obreros y Domésticas).
[9] Zaglul also states that she was seized for her opposition to the regime of Rafael Leónidas Trujillo and her strong criticism of the government, and that she was held in a fortress in San Pedro de Macoris and tortured.