On 7 June 1865, Evelina married her second cousin Ferdinand James von Rothschild (1839–1898) of the Austrian branch of the family.

Because of her parents' prominent position as one of the wealthiest and most influential families in England, guests at her wedding banquet and ball included Benjamin Disraeli, the ambassadors from Austria and France, and Prince George, Duke of Cambridge.

Following a lengthy honeymoon across Europe, Evelina and her husband settled into a home at 143 Piccadilly in London near her parents.

[1] In her memory, her husband built, equipped, and endowed the Evelina Hospital for Sick Children in Southwark, one of the neglected and poorest districts of London.

[3] Her mother, Charlotte, inaugurated the Evelina Prize, awarded at Jewish elementary schools and Jews' College.