[2][3] Sanguinetti announced her candidacy for the 2020 election in Illinois's 6th congressional district, challenging first-term Democratic incumbent Sean Casten, but dropped out on October 11, 2019.

[5] Sanguinetti's mother was a Cuban political refugee who was able to escape Cuba by way of Puerto Rico in the early 1960s before settling in the mainland United States.

[citation needed] Sanguinetti went on to attend Florida International University (FIU) and earned a bachelor's degree in music.

While a student she successfully handled the first ever case at the Chicago Commission on Human Relations that established a precedent for discrimination based on source of income.

[8] Sanguinetti won the election and served on the Wheaton City Council until December 2014 when she resigned to become Illinois Lieutenant Governor.

[12] From the report the task force produced a number of its recommendations subsequently became law;[13] Sanguinetti, as Lieutenant Governor, chaired the Mississippi, Illinois, Wabash and Ohio Rivers Coordinating Councils.

[19][20] One of the results of the Task Force was to make the opioid overdose reversal drug naloxone, commonly called Narcan, available without a prescription.

[22][23] Sanguinetti led a bipartisan effort to revive the Angel Investment Tax Credit in Illinois which helps small minority owned businesses.

[24] Sanguinetti, who chaired the Governor's Rural Affairs Council, worked with several state legislators on this bill, including Sen. Chuck Weaver (R-37), Sen. Dale Fowler (R-59), Sen. Daniel Biss (D-9), Rep. Grant Wehrli (R-41), Rep. Carol Sente (D59), Rep. Jaime Andrade Jr. (D-40) and Rep. Elgie Sims (D-34).