Adam Driver, Lena Dunham, Laura Ingraham, Jemima Kirke, Zosia Mamet, and Allison Williams guest starred.
Homer wakes up at the Springfield Nuclear Power Plant to an alarm, where he accidentally causes an electrical explosion at his desk.
The therapist says that Homer and Marge's relationship is falling apart and that the best option for them is separation, which could lead to divorce if things do not improve.
Homer tearfully packs his bags and leaves the family, with Marge admitting she is unsure when or if she will let him return.
After visiting Moe's Tavern, Homer goes to collect his medication, and meets a female pharmacist named Candace who agrees to go out with him, and they later spend the night together.
The camera pans out to reveal a tattoo of the entire scene on the back of Hannah Horvath from Girls.
A drug trip scene in the episode features "Big City (Everybody I Know Can be Found Here)", a 1991 song by the British band Spacemen 3.
[2] The band's co-founder and guitarist Peter Kember told The Wall Street Journal that the song's usage in the scene was "something that’s usually for me a high point of The Simpsons oeuvre.
"[2] In a September 2015, interview with The Hollywood Reporter, Al Jean spoke about the episode, saying: "We were trying to get to the nub of the answer to the marital dilemma.
"[3] The song playing during the couch gag was written and sung by Dan Castellaneta from his Beatles-inspired album.
[3] In January 2015, it was reported that Lena Dunham would guest star as a love interest for Homer while he is separated from Marge.
[5] In April 2015, Entertainment Weekly reported that Allison Williams, Zosia Mamet, and Jemima Kirke would appear as friends of Dunham's character.
The problem with this disastrously misguided season premiere is that the episode botches every one, exemplifying the current Simpsons lax and cynical tendencies before throwing the whole thing away with a series of handwaves so perfunctory as to render the entire episode not only thoroughly lousy, but completely inconsequential.
"[8] Jesse Schedeen of IGN gave the episode a 4.2 out of 10, saying "Perhaps there are still ways to get mileage out of the idea of Homer working to save his marriage, but this certainly isn't it.
This episode wasn't just redundant, it operated on flimsy logic, mostly ignored Marge and seemed to have no problem with the idea of Homer shacking up with another woman.
Worse, none of those problems even mattered in the end, because the whole thing proved to be one elaborate, pointless dream sequence.