In this episode, Principal Skinner and Bart both become infatuated with his new teacher while Lisa develops skin problems.
At Springfield Elementary, Superintendent Chalmers hires Carol Berrera as substitute teacher for the fourth grade.
At the party, Lisa sees rain which would reveal her acne problem, so she decides to take off the makeup in front of everybody first, but her skin is clean.
They start fighting, but they are separated by Maggie who now has a huge unibrow and super-strength due to the milk hormones.
He settled on a 1980s theme based on Miami Vice with some references to Saturday morning cartoons from that time.
Executive producer Al Jean left the door open for the character to return in future episodes.
Club gave the episode a B, stating "In the long history of Springfield’s questionable milk products, 'Teenage Mutant Milk-Caused Hurdles’ introduction of Buzz Milk, a hormone-heavy milk-like beverage from the makers of Buzz Cola, might not be up to the comedy standards of malk, or Squeaky Farms Brand Genuine Animal Milk, but the product’s effect of bringing 'precocious puberty' upon Bart and Lisa is also the catalyst for a surprisingly sweet, funny episode.
The idea of everyone’s favorite perpetual ten and eight-year-olds getting a patchy ‘stache (Bart) and pimples (Lisa) could have opened the door for a lot of the cynically 'risqué' jokes late-run Simpsons has been known to throw around...Instead, while the episode does suffer from a nondescript guest star and could use more time to fill out Bart and Lisa’s adventures in temporary teenager-dom, Joel H. Cohen’s script makes the kids’ confusion about their new state both character-appropriate and charming.
He thought Vergara's casting indicated a ratings stunt and that the long couch gag meant the episode was not fully fleshed out.