"Sister" Sarah Jane Butler, a hymn-humming religious fanatic who believes God has chosen her to cleanse the world of those who have sex for pleasure, seduces a bar patron, and guts him after the two leave together.

Sarah then drives to Los Angeles, and lures another man to his death, scrawling "God is Love, not Sex" on a mirror afterward.

While busking and preaching on the street, Sarah befriends Penelope von Prut, a naive lesbian who is being supported by her wealthy and ashamed parents.

Bill Gibron of DVD Verdict wrote "Wildly uneven, funny as Hell and occasional as disturbed as an actual psychopath, Evil Come Evil Go joins the ranks of other ridiculous exploitation romps, trying to hide their carnality with nonsensical narrative misdirection.

Pop!, who stated "Throw in an inexplicable guitar player who seems to pop up at random and serenade Sarah, a few great scenes where O'Hara’s crazed preacher interrupts a few couples in the midst of coitus and some great footage capturing the seedier side of early seventies Hollywood and it's easy to see why this one would have the cult following that it does.