[1] The series centers on wealthy crime lord Hector Con Carne, who is reduced to his brain and stomach after an assassination attempt and subsequently implanted onto Boskov, a purple Russian bear.

Aided by his scientist Major Dr. Ghastly and military leader General Skarr, Hector now oversees criminal organization Evil Con Carne, continuing his quest for world domination.

On December 1, 2023, 19 years after the show's final episode, reruns of Evil Con Carne began airing on Adult Swim on its throwback programming block, Checkered Past.

)Hector Con Carne (voiced by Phil LaMarr), a wealthy crime lord and evil genius bent on taking over the world and the League of Nations, was caught in an explosion initiated by his nemesis, Cod Commando (Maxwell Atoms), a soldier for the Secret Paramilitary Organized Response Kommand (S.P.O.R.K.).

He was rescued by the scientist Major Dr. Ghastly (Grey DeLisle), who placed his living remains into two containment units: one for his brain, and the other for his stomach.

Gathering an army, Con Carne resumed his quest for world domination and made a new goal: to find his missing body parts.

A viewer's poll to decide a new Cartoon Network animated series, titled Big Pick, was held on the Internet from June 16 to August 25, 2000.

According to Tom Warburton, characters from Evil Con Carne were originally set to appear in the television special "The Grim Adventures of the KND".

The episode's plot involves Hector and his army using a weapon that produces foul-smelling odors on New York City, sending its citizens into a frenzy.

After weeks of living together and preparations, Evil Con Carne's ultimate weapon is revealed to be an army of tanks that shoot giant rubber bands.