1580 — Don Juan de Garay, from Asunción of Paraguay, founds Buenos Aires for the second time to reaffirm the rights of the Spanish Crown against the Lusitanians' expansionist intentions.

One of the measures used in implementing this territorial defense, on October 24 of this year, is the distribution of land and many small farms among 25 neighbors who had accompanied Garay in the final founding of Buenos Aires.

1735 — On September 14, the day the Catholic Church celebrates the feast of the Exaltation of the Cross, the ecclesiastical authority raises the Casco de Mendoza's chapel to viceparish status, opening it up for public worship in 1750.

[2] 1750–1760 — The town of Capilla del Señor is established around the viceparish, fulfilling the Real Pragmatic of King Charles III which mandated that "all inhabitants rurally dispersed should be near a religious centre so their children can be educated in Christianity and in the first few letters".

As a result of the creation of these new partidos, Exaltación de la Cruz becomes an interior territory of Buenos Aires Province, no longer collecting taxes on merchandise entering via Zárate and Campana harbors.