Exercise-induced collapse

Signs are most likely to first become apparent in young dogs when they enter heavy training, which is usually between 5 months and 1 year of age.

Dogs with this condition are always normal at rest and are described as being extremely fit, prime athletic specimens of their breed.

This gene is a protein that plays a key role in repackaging synaptic vesicles containing neurotransmitters.

The action of DNM1 is only triggered with a high level of sustained exercise when it is needed for synaptic transmission in the brain and spinal cord.

[4][5] Through grants from the AKC CHF a patented DNA test was developed by the University of MN.

The UMN VBS Genetics Lab is also investigating cases of "atypical collapse"[7] and also "Border Collie Collapse"[8] where the dog is a carrier or clear of the disease on the DNA test, but continues to exhibit signs of the EIC disease.