Written by lead vocalist, guitarist and pianist Matthew Bellamy over the course of a number of years, the piece is presented as a symphony in three movements entitled "Overture", "Cross-Pollination" and "Redemption", respectively, each occupying a separate track at the end of the album and spanning nearly 13 minutes in total.

"[3] This idea was later discussed further and in a more extreme sense, when Bellamy suggested that the band may reject the conventional album format in favour of releasing a series of singles, or indeed "one 50-minute symphony.

In a pre-release interview with the band, NME identified "Exogenesis" as one of the highlights of the album, describing it as "more bombastic than anything Muse have ever previously done" and revealing that it features "classical piano from Bellamy and a full orchestra throughout.

"[10] French media source JudeBox reviewed the album before its release, comparing Bellamy's vocal performance to that of Radiohead frontman Thom Yorke and identifying classical composers Frédéric Chopin and Franz Liszt as influences for the symphony.

[13] The feature article quoted bassist and backing vocalist Christopher Wolstenholme as saying the following on the song: You can always just take the band away from that track and just have the orchestral bit and it would still be beautiful.

[14] "Exogenesis: Symphony Part I" was used for Dior Homme's advertisement called "A Rendezvous", directed by Guy Ritchie and starring Jude Law and Michaela Kocianova.

[15][16] In September 2012, three years after the release of The Resistance and "Exogenesis", Charles Bollfrass claimed that the "Symphony" copied his original cinematic project with the same name.

The following year, Muse told him they were not interested in pursuing the project, but System of a Down's lead guitarist, Daron Malakian, had said yes, announcing his band's hiatus during an MTV interview.

But while Judge Stanton tossed the lawsuit, he denied Warner Music's request for attorneys' fees, saying "there was no evidence to conclude that Bollfrass' complaint was frivolous.

[24] All tracks are written by Matthew BellamyTouring members: Morgan Nicholls (2004, 2006–2022), Daniel Newell (2006–2008), Alessandro Cortini (2009), Dan Lancaster (2022–present)