She made seven voyages for Calvert & Co. as a slave ship in the triangular trade in enslaved people, carrying captives from the Gold Coast to Jamaica.

Experiment appears in Lloyd's Register for 1789 with R. Owen, master, Calvert & Co., owners, and trade London—Africa.

1st enslaving voyage (1789-1790): Richard Owen was her master for the first, with Diederick Woolbert replacing him at some point in the venture.

[6] 2nd enslaving voyage (1790-1791): Captain Diederick Woolbert sailed from Jamaica in August, straight back to Africa.

Experiment starting to gather captives on 9 November, first at Cape Coast Castle and then at Anomabu.

[8] 4th enslaving voyage (1792): Captain John Marman sailed straight back to Africa from Jamaica in April.

[9] 5th enslaving voyage (1792-1793): Captain Marman sailed from Jamaica on 28 August 1792, and started gathering captives at Cape Coast Castle and then Anomabu.

[13] The Trans-Atlantic Slave Trade database reports that Experiment was recaptured or released subsequently, but as of November 2022, it has not been verified.

[14] During the period 1793 to 1807, war, rather than maritime hazards or resistance by the captives, was the greatest cause of vessel losses among British slave ships.