[citation needed] Inhabited originally by the Querandí people, the land was then claimed by the Conquistadores in 1588.

The first estancia (Los Remedios) and chapel in the area were founded by Juan Guillermo González y Aragón in 1758; one of González's great-grandsons was Manuel Belgrano, one of the most notable leaders of the Argentine War of Independence.

Following his death, Ezeiza's son-in-law donated land to the Buenos Aires Western Railway, and the town was founded around the new line on 17 July 1885; it was named in honor of the late José María Ezeiza.

[2] The freeway was scene of the Ezeiza Massacre, in which at least 13 died in clashes between left and right-wing Peronists vying for the best vantage points from which to view the motorcade for exiled former President Juan Perón upon his return to Argentina on 20 June 1973.

The Bosques de Ezeiza ('Ezeiza Woods') are likewise an important tourist attraction for the area.