Ezekiel Pickens (March 30, 1768 – May 22, 1813) was an American lawyer and politician; he served as the Lieutenant Governor of South Carolina from 1802 to 1804.
Returning to South Carolina, Pickens studied law and was admitted to the bar in 1793.
Pickens' family were land speculators and leaders of the western South Carolina settlers.
His aunt Floride Bonneau (~1761-1836) married John E. Colhoun, a long-time member of the South Carolina House who served as a US Senator from 1801 until his death in 1802.
Their daughter Floride Bonneau Colhoun (Ezekiel Picken's first cousin) married John C. Calhoun, Vice President from 1825 to 1832.