It bears some relationship to the earlier Cernavodă III culture to the north.

The Ezero culture is interpreted as part of a larger Balkan-Danubian early Bronze Age complex, a horizon reaching from Troy Id-IIc into Central Europe, encompassing the Baden of the Carpathian Basin and the Coţofeni culture of Romania.

According to Hermann Parzinger, there are also typological connections to Poliochne IIa-b and Sitagroi IV.

It could also represent an Anatolian-influenced culture, either coming from Anatolia (in Renfrew's hypothesis), or heading to Asia Minor.

Genetic studies have shown that the Ezero culture had a male haplogroup R1b.