With over 70 film credits (and dozens of television appearances), Buzzington has been referred to as "the Dennis Hopper of underground cinema".

He has played characters ranging from "Weird Al the Waiter" in Ghost World to "Goggle" (a mutant) in The Hills Have Eyes and Tudley in the Crime thriller film The Chair.

He has worked with directors David Fincher (twice), Alexandre Aja (twice), Terry Zwigoff (twice), Rob Zombie (twice), David Slade (four times), Steven Spielberg, Christopher Nolan, Paul Thomas Anderson, George Clooney, Clint Eastwood and the Farrelly Brothers (also twice).

He was a series regular in the role of Oswald Eisengrim on NBC's Crossbones opposite John Malkovich's Blackbeard, recurred on NBC's Law & Order True Crime as DDA Elliot Alhadeff, recurred on ABC's The Middle as the hard of hearing co-worker of Neil Flynn's character, starred in an episode of CBS's How I Met Your Mother and made several appearances on Justified for FX.

[citation needed] He is also the creator of Theatrism, a metaphysical approach to theatrical staging.